Figure vi. Genes that cluster with the MAP kinase HOG1.
The "WSC2 cluster" and the highly-similar "CIS3 cluster" are shown as they appear in the genomic cluster shown in Figure 1. An asterisk in the gene annotation indicates genes adjacent on this display that are likely to cross-hybridize on the arrays.

Many encoded protein kinases are autoregulated at the level of gene expression. Thus, the induction of an encoded signaling factor suggests the activity of the pathway it participates in and also implicates the genes that it clusters with as targets of the pathway. Thus, the expression of genes that cluster with the MAP kinase HOG1 may be affected by activity of this pathway. Many of the genes in these clusters encode putative cell wall proteins, enzymes involved in cell wall biosynthesis, or uncharacterized proteins with putative signal sequences, suggesting their possible localization to the cell wall. Furthermore, the putative cell wall sensor WSC2 is also highly correlated to these genes, raising the possibility that it is involved in their regualtion. Unlike the genes that cluster with the MAP kinase of the PKC pathway, these putative cell wall genes are induced exclusively by DTT and diamide treatment.