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Figure iii. Genomic expression in response to MMS is highly similar in mec1 and dun1 mutant cells. Linear regression analysis was performed to compare the overall genomic expression responses in wild-type, mec1, and dun1 cells responding to MMS. Log2 expression values measured for approximately 850 genes that changed more than two-fold in wild-type cells were plotted for all of the analyses shown. (A) Log2 expression values measured at 30, 90, and 120 minutes after MMS treatment in wild-type cells (x-axes) versus mec1 cells (y-axes) were plotted and fit to linear curves. (B) Log2 expression values measured at 30, 90, and 120 minutes after MMS treatment in mec1 cells (x-axes) versus dun1 cells (y-axes) were plotted and fit to a linear curve. The linear fit of each curve is represented by the equation shown in the upper left corner of each plot. |